Fiche publication
Date publication
janvier 2021
Journal
PLoS neglected tropical diseases
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CRIBIER Bernard
Tous les auteurs :
Fernando DD, Reynolds SL, Hartel G, Cribier B, Ortonne N, Jones MK, Fischer K
Lien Pubmed
Résumé
Scabies, a highly contagious skin disease affecting more than 200 million people worldwide at any time, is caused by the parasitic mite Sarcoptes scabiei. In the absence of molecular markers, diagnosis requires experience making surveillance and control challenging. Superficial microthrombi in the absence of vasculitis in scabies-affected skin are a recognised, yet unexplained histopathological differential of scabies infection. This study demonstrates that a family of Scabies Mite Inactivated Cysteine Protease Paralogues (SMIPP-Cs) excreted by the mites plays a role in formation of scabies-induced superficial microthrombi.
Référence
PLoS Negl Trop Dis. 2021 Jan 6;15(1):e0008997
