Density of surface charge is a more predictive factor of the toxicity of cationic carbon nanoparticles than zeta potential.

Fiche publication

Date publication

janvier 2021

Journal

Journal of nanobiotechnology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr LEBEAU Luc , Pr PONS Françoise , Pr DIDIER Pascal

Tous les auteurs :
Weiss M, Fan J, Claudel M, Sonntag T, Didier P, Ronzani C, Lebeau L, Pons F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/33407567

Résumé

A positive surface charge has been largely associated with nanoparticle (NP) toxicity. However, by screening a carbon NP library in macrophages, we found that a cationic charge does not systematically translate into toxicity. To get deeper insight into this, we carried out a comprehensive study on 5 cationic carbon NPs (NP2 to NP6) exhibiting a similar zeta (ζ) potential value (from + 20.6 to + 26.9 mV) but displaying an increasing surface charge density (electrokinetic charge, Q from 0.23 to 4.39 µmol/g). An anionic and non-cytotoxic NP (NP1, ζ-potential = - 38.5 mV) was used as control.