Fiche publication
Date publication
janvier 2021
Journal
Journal of nanobiotechnology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BEZDETNAYA-BOLOTINE Lina
Tous les auteurs :
Yakavets I, Francois A, Lamy L, Piffoux M, Gazeau F, Wilhelm C, Zorin V, Silva AKA, Bezdetnaya L
Lien Pubmed
Résumé
Despite the highly expected clinical application of nanoparticles (NPs), the translation of NPs from lab to the clinic has been relatively slow. Co-culture 3D spheroids account for the 3D arrangement of tumor cells and stromal components, e.g., cancer-associated fibroblasts (CAFs) and extracellular matrix, recapitulating microenvironment of head and neck squamous cell carcinoma (HNSCC). In the present study, we investigated how the stroma-rich tumor microenvironment affects the uptake, penetration, and photodynamic efficiency of three lipid-based nanoformulations of approved in EU photosensitizer temoporfin (mTHPC): Foslip (mTHPC in conventional liposomes), drug-in-cyclodextrin-in-liposomes (mTHPC-DCL) and extracellular vesicles (mTHPC-EVs).
Mots clés
Drug penetration, Drug-in-cyclodextrin-in-liposomes, Extracellular matrix, Extracellular vesicles, Multicellular tumor spheroids, Photodynamic therapy, Temoporfin
Référence
J Nanobiotechnology. 2021 Jan 6;19(1):3
