Fiche publication
Date publication
juillet 2015
Journal
Chemical communications (Cambridge, England)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MELY Yves
,
Dr REMY Jean-Serge
,
Dr WAGNER Alain
,
Dr KLYMCHENKO Andrey
Tous les auteurs :
Neuberg P, Perino A, Morin-Picardat E, Anton N, Darwich Z, Weltin D, Mely Y, Klymchenko AS, Remy JS, Wagner A
Lien Pubmed
Résumé
A series of polydiacetylene (PDA) - based micelles were prepared from diacetylenic surfactant bearing polyethylene glycol, by increasing UV-irradiation times. These polymeric lipid micelles were analyzed by physicochemical methods, electron microscopy and NMR analysis. Cellular delivery of fluorescent dye suggests that adjusting the polymerization state is vital to reach the full in vitro potential of PDA-based delivery systems.
Mots clés
Cell Line, Cell Survival, drug effects, Drug Delivery Systems, Fluorescent Dyes, administration & dosage, HeLa Cells, Humans, Micelles, Oxazines, administration & dosage, Polyacetylenes, chemistry, Polyethylene Glycols, chemistry, Polymerization, Polymers, chemistry, Surface-Active Agents, chemistry, Ultraviolet Rays
Référence
Chem. Commun. (Camb.). 2015 Jul;51(58):11595-8
