Elastase and Exacerbation of Neutrophil Innate Immunity are Involved in Multi-Visceral Manifestations of COVID-19.

Date publication

janvier 2021

Journal

Allergy

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis , Dr OUSSALAH Abderrahim

Tous les auteurs :
Guéant JL, Guéant-Rodriguez RM, Fromonot J, Oussalah A, Louis H, Chery C, Gette M, Gleye S, Callet J, Raso J, Blanchecotte F, Lacolley P, Guieu R, Regnault V

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/33484168

Résumé

Many arguments suggest that neutrophils could play a prominent role in COVID-19. However, the role of key components of neutrophil innate immunity in severe forms of COVID-19 has deserved insufficient attention. We aimed to evaluate the involvement of Neutrophil Elastase, histone-DNA, and DNases in systemic and multi-organ manifestations of COVID-19.

Mots clés

COVID-19, DNase, innate immunity, myeloperoxidase, neutrophil elastase, neutrophil extracellular traps (NETs), neutrophils

Référence

Allergy. 2021 Jan 23;: