Fiche publication
Date publication
octobre 2010
Journal
Anticancer research
Auteurs
Membres identifiés du Cancéropôle Est :
Dr HOULGATTE Rémy
,
Dr ROLLAND Delphine
Tous les auteurs :
Rolland D, Raharijaona M, Barbarat A, Houlgatte R, Thieblemont C
Lien Pubmed
Résumé
Mantle cell lymphoma (MCL) is a chemoresistant lymphoma overexpressing the class pi glutathione-S-transferase (GST-pi). The nuclear localisation of GST-pi is induced by chemotherapy and is correlated to cell resistance. In this study, the effect of the Agaricus bisporus lectin (ABL), a GST-pi nuclear transfer inhibitor, on the chemosensitivity of MCL cells was investigated.
Mots clés
Active Transport, Cell Nucleus, drug effects, Antineoplastic Agents, pharmacology, Antineoplastic Combined Chemotherapy Protocols, pharmacology, Boronic Acids, administration & dosage, Bortezomib, Cell Growth Processes, drug effects, Cell Line, Tumor, Cisplatin, administration & dosage, Cytarabine, administration & dosage, Deoxycytidine, administration & dosage, Doxorubicin, administration & dosage, Drug Screening Assays, Antitumor, Glutathione S-Transferase pi, antagonists & inhibitors, Humans, Lectins, administration & dosage, Lymphoma, Mantle-Cell, drug therapy, Pyrazines, administration & dosage
Référence
Anticancer Res.. 2010 Oct;30(10):3951-7
