Gene Expression Profiling of Mediastinal Gray Zone Lymphoma and Its Relationship to Primary Mediastinal B-cell Lymphoma and Classical Hodgkin Lymphoma.

Date publication

septembre 2020

Journal

Blood cancer discovery

Auteurs

Membres identifiés du Cancéropôle Est :
Dr NICOLAE Alina

Tous les auteurs :
Pittaluga S, Nicolae A, Wright GW, Melani C, Roschewski M, Steinberg S, Huang D, Staudt LM, Jaffe ES, Wilson WH

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/32914098

Résumé

Mediastinal gray zone lymphoma (MGZL) has immunopathologic features between classical Hodgkin lymphoma (cHL) and primary mediastinal thymic B-cell lymphoma (PMBL), leading to uncertainty regarding its biological relationship to these entities. We performed gene expression profiling from patients with MGZL (20), cHL (18), and PMBL (17) and show MGZL clusters between cHL and PMBL. Expression signatures reveal germinal B-cell and IFN regulatory factor 4 (IRF4) signatures were relatively low in MGZL and cHL compared with PMBL, indicating downregulation of the B-cell program in MGZL, a hallmark of cHL. T-cell and macrophage signatures were higher in MGZL and cHL compared with PMBL, consistent with infiltrating immune cells, which are found in cHL. The NFκB signature was higher in MGZL than PMBL, and like cHL, MGZL and PMBL express NFκB inducing kinase (NIK), indicating noncanonical signaling. These findings indicate that while MGZL has distinctive clustering, it is biologically closer to cHL.

Référence

Blood Cancer Discov. 2020 Sep 1;1(2):155-161