Fiche publication
Date publication
juin 2015
Journal
Nature communications
Auteurs
Membres identifiés du Cancéropôle Est :
Dr YUSUPOV Marat
,
Dr YUSUPOVA Gulnara
,
Dr BEN SHEM Adam
Tous les auteurs :
Melnikov S, Ben-Shem A, Yusupova G, Yusupov M
Lien Pubmed
Résumé
Eukaryotic ribosomal proteins, unlike their bacterial homologues, possess nuclear localization signals (NLSs) to enter the cell nucleus during ribosome assembly. Here we provide a comprehensive comparison of bacterial and eukaryotic ribosomes to show that NLSs appear in conserved ribosomal proteins via remodelling of their RNA-binding domains. This finding enabled us to identify previously unknown NLSs in ribosomal proteins from humans, and suggests that, apart from promoting protein transport, NLSs may facilitate folding of ribosomal RNA.
Mots clés
Amino Acid Sequence, Binding Sites, Cell Nucleus, metabolism, Conserved Sequence, Escherichia coli, Escherichia coli Proteins, chemistry, HEK293 Cells, HeLa Cells, Humans, Nuclear Localization Signals, chemistry, Protein Transport, RNA, Ribosomal, metabolism, RNA-Binding Proteins, chemistry, Ribosomal Proteins, chemistry, Ribosomes, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, chemistry
Référence
Nat Commun. 2015 Jun 11;6:7382
