Fiche publication
Date publication
février 2021
Journal
Pharmaceuticals (Basel, Switzerland)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FROCHOT Céline
Tous les auteurs :
Myrzakhmetov B, Arnoux P, Mordon S, Acherar S, Tsoy I, Frochot C
Lien Pubmed
Résumé
Photodynamic therapy (PDT) is an innovative treatment of malignant or diseased tissues. The effectiveness of PDT depends on light dosimetry, oxygen availability, and properties of the photosensitizer (PS). Depending on the medium, photophysical properties of the PS can change leading to increase or decrease in fluorescence emission and formation of reactive oxygen species (ROS) especially singlet oxygen (O). In this study, the influence of solvent polarity, viscosity, concentration, temperature, and pH medium on the photophysical properties of protoporphyrin IX, pyropheophorbide-a, and Photofrin were investigated by UV-visible absorption, fluorescence emission, singlet oxygen emission, and time-resolved fluorescence spectroscopies.
Mots clés
Photofrin®, absorption, fluorescence, photodynamic therapy, protoporphyrin IX, pyropheophorbide-a, singlet oxygen
Référence
Pharmaceuticals (Basel). 2021 Feb 9;14(2):
