Deletion of Stearoyl-CoA Desaturase-1 From the Intestinal Epithelium Promotes Inflammation and Tumorigenesis, Reversed by Dietary Oleate.

Fiche publication

Date publication

novembre 2018

Journal

Gastroenterology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr PLATEROTI Michelina

Tous les auteurs :
Ducheix S, Peres C, Härdfeldt J, Frau C, Mocciaro G, Piccinin E, Lobaccaro JM, De Santis S, Chieppa M, Bertrand-Michel J, Plateroti M, Griffin JL, Sabbà C, Ntambi JM, Moschetta A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30063922

Résumé

The enzyme stearoyl-coenzyme A desaturase 1 (SCD or SCD1) produces monounsaturated fatty acids by introducing double bonds into saturated bonds between carbons 9 and 10, with oleic acid as the main product. SCD1 is present in the intestinal epithelium, and fatty acids regulate cell proliferation, so we investigated the effects of SCD1-induced production of oleic acid in enterocytes in mice.