Fiche publication
Date publication
février 2021
Journal
Respiratory research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr POLETTE Myriam
,
Dr DORMOY Valerian
Tous les auteurs :
Perotin JM, Polette M, Deslée G, Dormoy V
Lien Pubmed
Résumé
The pathophysiology of chronic obstructive pulmonary disease (COPD) relies on airway remodelling and inflammation. Alterations of mucociliary clearance are a major hallmark of COPD caused by structural and functional cilia abnormalities. Using transcriptomic databases of whole lung tissues and isolated small airway epithelial cells (SAEC), we comparatively analysed cilia-associated and ciliopathy-associated gene signatures from a set of 495 genes in 7 datasets including 538 non-COPD and 508 COPD patients. This bio-informatics approach unveils yet undescribed cilia and ciliopathy genes associated with COPD including NEK6 and PROM2 that may contribute to the pathology, and suggests a COPD endotype exhibiting ciliopathy features (CiliOPD).
Mots clés
COPD, Cilia, Transcriptomic
Référence
Respir Res. 2021 Feb 27;22(1):74
