Fiche publication
Date publication
février 2021
Journal
Cancers
Auteurs
Membres identifiés du Cancéropôle Est :
Pr COTTIN Yves
,
Pr VERGELY Catherine
Tous les auteurs :
Rochette L, Zeller M, Cottin Y, Vergely C
Lien Pubmed
Résumé
Understanding the structure and dynamics of the various hydrogen forms has been a subject of numerous studies. Protons (H) and molecular hydrogen (H) in the cell are critical in a wide variety of processes. A new cancer treatment uses H, a biologically inactive gas. Due to its small molecular weight, H can rapidly penetrate cell membranes and reach subcellular components to protect nuclear DNA and mitochondria. H reduces oxidative stress, exerts anti-inflammatory effects, and acts as a modulator of apoptosis. Exogenous H, administered by inhalation, drinking H-rich water, or injecting H-rich saline solution, is a protective therapy that can be used in multiple diseases, including cancer. In particle therapy, cyclotrons and synchrotrons are the accelerators currently used to produce protons. Proton beam radiotherapy (PBT) offers great promise for the treatment of a wide variety of cancers due to the sharp decrease in the dose of radiation at a defined point. In these conditions, H and different types of H donors may represent a novel therapeutic strategy in cancer treatment.
Mots clés
antioxidant, cancer, molecular hydrogen
Référence
Cancers (Basel). 2021 Feb 20;13(4):
