Fiche publication
Date publication
février 2021
Journal
Molecules (Basel, Switzerland)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FROCHOT Céline
Tous les auteurs :
Le Guern F, Ouk TS, Yerzhan I, Nurlykyz Y, Arnoux P, Frochot C, Leroy-Lhez S, Sol V
Lien Pubmed
Résumé
Despite advances achieved over the last decade, infections caused by multi-drug-resistant bacterial strains are increasingly becoming important societal issues that need to be addressed. New approaches have already been developed in order to overcome this problem. Photodynamic antimicrobial chemotherapy (PACT) could provide an alternative to fight infectious bacteria. Many studies have highlighted the value of cationic photosensitizers in order to improve this approach. This study reports the synthesis and the characterization of cationic porphyrins derived from methylimidazolium and phenylimidazolium porphyrins, along with a comparison of their photophysical properties with the well-known -methylpyridyl (pyridinium) porphyrin family. PACT tests conducted with the tetracationic porphyrins of these three families showed that these new photosensitizers may offer a good alternative to the classical pyridinium porphyrins, especially against and . In addition, they pave the way to new cationic photosensitizers by the means of derivatization through amide bond formation.
Mots clés
antimicrobial, cationic, photodynamic, photophysical, porphyrin, properties, therapy
Référence
Molecules. 2021 Feb 20;26(4):
