Cardiovascular manifestations of intermediate and major hyperhomocysteinemia due to vitamin B12 and folate deficiency and/or inherited disorders of one-carbon metabolism: a 3.5-year retrospective cross-sectional study of consecutive patients.

Date publication

mars 2021

Journal

The American journal of clinical nutrition

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis , Dr OUSSALAH Abderrahim

Tous les auteurs :
Levy J, Rodriguez-Guéant RM, Oussalah A, Jeannesson E, Wahl D, Ziuly S, Guéant JL

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/33693455

Résumé

The association of moderate hyperhomocysteinemia (HHcy) (15-30 μmol/L) with cardiovascular diseases (CVD) has been challenged by the lack of benefit of vitamin supplementation to lowering homocysteine. Consequently, the results of interventional studies have confused the debate regarding the management of patients with intermediate/severe HHcy.

Mots clés

1-carbon metabolism, cardiovascular disease risk, folate, homocysteine, inborn errors of metabolism, thromboembolic manifestations, vitamin B12

Référence

Am J Clin Nutr. 2021 Mar 10;: