Fiche publication
Date publication
janvier 2021
Journal
Frontiers in cell and developmental biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GIANGRANDE Angela
,
Dr CATTENOZ Pierre
Tous les auteurs :
Cattenoz PB, Monticelli S, Pavlidaki A, Giangrande A
Lien Pubmed
Résumé
The catalog of the immune cells was until recently limited to three major cell types, based on morphology, function and few molecular markers. Three recent single cell studies highlight the presence of several subgroups, revealing a large diversity in the molecular signature of the larval immune cells. Since these studies rely on somewhat different experimental and analytical approaches, we here compare the datasets and identify eight common, robust subgroups associated to distinct functions such as proliferation, immune response, phagocytosis or secretion. Similar comparative analyses with datasets from different stages and tissues disclose the presence of larval immune cells resembling embryonic hemocyte progenitors and the expression of specific properties in larval immune cells associated with peripheral tissues.
Mots clés
drosophila, innate immunity, lamellocyte, macrophage, single cell RNA seq
Référence
Front Cell Dev Biol. 2021 ;9:643712
