Fiche publication
Date publication
mars 2021
Journal
Journal of clinical medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr COUTANT Charles
,
Pr AKLADIOS Chérif
Tous les auteurs :
Rocher G, Gaillard T, Uzan C, Collinet P, Bolze PA, Ballester M, Bendifallah S, Ouldamer L, Touboul C, Huchon C, Lavoue V, Dabi Y, Akladios C, Coutant C, Raimond E, Bricou A, Canlorbe G, Azaïs H
Lien Pubmed
Résumé
To determine if the time-to-chemotherapy (TTC) after primary macroscopic complete cytoreductive surgery (CRS) influences recurrence-free survival (RFS) and overall survival (OS) in patients with epithelial ovarian cancer (EOC). We conducted an observational multicenter retrospective cohort analysis of women with EOC treated from September 2006 to November 2016 in nine institutions in France (FRANCOGYN research group) with maintained EOC databases. We included women with EOC (all FIGO stages) who underwent primary complete macroscopic CRS prior to platinum-based adjuvant chemotherapy. Two hundred thirty-three patients were included: 73 (31.3%) in the early-stage group (ESG) (FIGO I-II), and 160 (68.7%) in the advanced-stage group (ASG) (FIGO III-IV). Median TTC was 43 days (36-56). The median OS was 77.2 months (65.9-106.6). OS was lower in the ASG when TTC exceeded 8 weeks (70.5 vs. 59.3 months, = 0.04). No impact on OS was found when TTC was below or above 6 weeks (78.5 and 66.8 months, respectively, = 0.25). In the whole population, TTC had no impact on RFS or OS. None of the factors studied were associated with an increase in TTC. Chemotherapy should be initiated as soon as possible after CRS. A TTC greater than 8 weeks is associated with poorer OS in patients with advanced stage EOC.
Mots clés
chemotherapy, epithelial ovarian cancer, prognosis
Référence
J Clin Med. 2021 Mar 4;10(5):