Fiche publication
Date publication
mars 2021
Journal
Mathematical biosciences and engineering : MBE
Auteurs
Membres identifiés du Cancéropôle Est :
Pr PRUD'HOMME Christophe
Tous les auteurs :
Prud'homme C, Sala L, Szopos M
Lien Pubmed
Résumé
We propose an uncertainty propagation study and a sensitivity analysis with the Ocular Mathematical Virtual Simulator, a computational and mathematical model that predicts the hemodynamics and biomechanics within the human eye. In this contribution, we focus on the effect of intraocular pressure, retrolaminar tissue pressure and systemic blood pressure on the ocular posterior tissue vasculature. The combination of a physically-based model with experiments-based stochastic input allows us to gain a better understanding of the physiological system, accounting both for the driving mechanisms and the data variability.
Mots clés
Sobol index analysis , computational model , ocular mathematical virtual simulator , predictive ocular vascular dynamics , sensitivity analysis , uncertainty quantification
Référence
Math Biosci Eng. 2021 Mar 2;18(3):2010-2032
