Performance of Next Generation Sequencing for the Detection of Microsatellite Instability in Colorectal Cancer with Deficient DNA Mismatch Repair.

Date publication

mai 2021

Journal

Gastroenterology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GHIRINGHELLI François

Tous les auteurs :
Ratovomanana T, Cohen R, Svrcek M, Renaud F, Cervera P, Siret A, Letourneur Q, Buhard O, Bourgoin P, Guillerm E, Dorard C, Nicolle R, Ayadi M, Touat M, Bielle F, Sanson M, Le Rouzic P, Buisine MP, Piessen G, Collura A, Fléjou JF, de Reynies A, Coulet F, Ghiringhelli F, André T, Jonchère V, Duval A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/33992635

Résumé

Next generation sequencing (NGS) was recently approved by the FDA to detect microsatellite instability (MSI) arising from defective mismatch repair (dMMR) in patients with metastatic colorectal cancer (mCRC) prior to treatment with immune checkpoint inhibitors (ICI). In this study, we aimed to evaluate and improve the performance of NGS to identify MSI in CRC, especially dMMR mCRC treated with ICI.

Mots clés

Diagnostic test, Immunotherapy, Microsatellite instability (MSI), Mismatch repair deficiency (dMMR), Next-generation sequencing, Reference methods

Référence

Gastroenterology. 2021 May 13;: