Fiche publication
Date publication
avril 2021
Journal
European journal of medicinal chemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BETTAIEB Ali
,
Pr PAUL Catherine
,
Pr DENAT Franck
,
Dr COLLIN Bertrand
,
Dr BELLAYE Pierre-Simon
Tous les auteurs :
Lescure R, Privat M, Pliquett J, Massot A, Baffroy O, Busser B, Bellaye PS, Collin B, Denat F, Bettaïeb A, Sancey L, Paul C, Goze C, Bodio E
Lien Pubmed
Résumé
Three near-infrared (NIR-I) optical theranostic systems were synthesized, characterized and studied in vitro and in vivo. These original homo-bimetallic gold(I)-based aza-BODIPY complexes proved to be trackable through near-infrared optical imaging in cells and in mice. They display anti-proliferative properties in micromolar range against human and murine cancer cell lines (4T1, MDA-MB-231, CT26, and SW480). Moreover, the injection of the most promising theranostic agent in CT26 tumor-bearing BALB/c mice induced a significant anti-cancer activity.
Mots clés
Gold complexes, NIR fluorescence, Theranostics, aza-BODIPY, cancer, optical imaging
Référence
Eur J Med Chem. 2021 Apr 19;220:113483
