Fiche publication
Date publication
juin 2021
Journal
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GOBINET Cyril
,
Pr PIOT Olivier
Tous les auteurs :
Essendoubi M, Alsamad F, Noël P, Meunier M, Scandolera A, Sandré J, Manfait M, Gobinet C, Reynaud R, Piot O
Lien Pubmed
Résumé
Monitoring the transcutaneous permeation of exogenous molecules using conventional techniques generally requires long pre-analytical preparation or labelling of samples. However, Raman spectroscopy is a label-free and non-destructive method which provides spatial distribution of tracked actives in skin. The aim of our study was to prove the interest of Raman imaging coupled with multivariate curve resolution alternating least square (MCR-ALS) analysis in monitoring retinol penetration into frozen and living human skin.
Mots clés
MCR-ALS analysis, Raman imaging, human skin, retinol, transcutaneous permeation
Référence
Skin Res Technol. 2021 Jun 11;:
