Fiche publication
Date publication
juin 2021
Journal
Molecules (Basel, Switzerland)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DELSUC Marc-André
Tous les auteurs :
Delsuc MA, Breuker K, van Agthoven MA
Lien Pubmed
Résumé
Two-dimensional mass spectrometry (2D MS) is a tandem mass spectrometry method that relies on manipulating ion motions to correlate precursor and fragment ion signals. 2D mass spectra are obtained by performing a Fourier transform in both the precursor ion mass-to-charge ratio () dimension and the fragment ion dimension. The phase of the ion signals evolves linearly in the precursor dimension and quadratically in the fragment dimension. This study demonstrates that phase-corrected absorption mode 2D mass spectrometry improves signal-to-noise ratios by a factor of 2 and resolving power by a factor of 2 in each dimension compared to magnitude mode. Furthermore, phase correction leads to an easier differentiation between ion signals and artefacts, and therefore easier data interpretation.
Mots clés
absorption mode, data processing, mass spectrometry, phase correction, tandem mass spectrometry, two-dimensional
Référence
Molecules. 2021 Jun 3;26(11):
