Fiche publication
Date publication
juillet 2021
Journal
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PEIGNAUX Karine
,
Pr TRUC Gilles
,
Dr BESSIERES Igor
,
Dr ROUFFIAC-THOUANT Magali
Tous les auteurs :
Rouffiac M, Ghirardi S, Chevalier C, Bessières I, Peignaux-Casasnovas K, Truc G, Créhange G
Lien Pubmed
Résumé
Pancreatic cancer has poor prognosis and a continuously growing incidence. By 2030, it should become the second cause of death by cancer worldwide and in France. The only curative treatment is surgery that is achievable in only 20% of patients at the time of initial diagnosis, with a high rate of incomplete resection. Neoadjuvant treatments using chemotherapy with or without radiotherapy are more often admitted to play an important role by selecting non-progressing cases who will benefit from surgery, by increasing the number of complete resection, and by making locally advanced and borderline tumours accessible to resection. However, the role of radiotherapy is still debated. Because of its dosimetric advantages, its short total duration, and its good tolerance with reduced volumes of irradiation, stereotactic radiotherapy has been largely studied. Compared to chemoradiotherapy, this technique could improve the therapeutic index helping to preserve the general status of patients in order to give them access to secondary surgery. It remains a promising technique still under evaluation, to be delivered ideally, as part of a clinical trial, or within an experimented team.
Mots clés
Borderline, Cancer du pancréas, Localement avancé, Locally advanced, Pancreatic cancer, Radiothérapie stéréotaxique, Stereotactic radiotherapy
Référence
Cancer Radiother. 2021 Jul 17;:
