Fiche publication
Date publication
juillet 2021
Journal
International journal of molecular sciences
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PAIS DE BARROS Jean-Paul
,
Pr MASSON David
Tous les auteurs :
Gaillard D, Masson D, Garo E, Souidi M, Pais de Barros JP, Schoonjans K, Grober J, Besnard P, Thomas C
Lien Pubmed
Résumé
Hypercholesterolemia is a major risk factor for atherosclerosis and cardiovascular diseases. Although resistant to hypercholesterolemia, the mouse is a prominent model in cardiovascular research. To assess the contribution of bile acids to this protective phenotype, we explored the impact of a 2-week-long dietary cholesterol overload on cholesterol and bile acid metabolism in mice.
Mots clés
FXR, LXR, bile acids, cholesterol, hypercholesterolemia
Référence
Int J Mol Sci. 2021 Jul 2;22(13):
