Respective roles of Glycoprotein VI and FcγRIIA in the regulation of αIIbβ3-mediated platelet activation to fibrinogen, thrombus buildup, and stability.

Date publication

juillet 2021

Journal

Research and practice in thrombosis and haemostasis

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GACHET Christian , Dr MANGIN Pierre

Tous les auteurs :
Ahmed MU, Receveur N, Janus-Bell E, Mouriaux C, Gachet C, Jandrot-Perrus M, Hechler B, Gardiner EE, Mangin PH

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/34263103

Résumé

The interplay between platelets and fibrinogen is the cornerstone of thrombus formation. Integrin αIIbβ3 is the main platelet adhesion receptor for fibrinogen and mediates an outside-in signal upon ligand binding that reinforces platelet activation. In addition, FcγRIIA and glycoprotein VI (GPVI) contribute to platelet activation on fibrinogen, thereby participating in thrombus growth and stability. To date, the relative importance of these two immunoreceptor tyrosine-based activation motif-bearing receptors in these processes remains unknown.

Référence

Res Pract Thromb Haemost. 2021 Jul;5(5):e12551