Fiche publication
Date publication
mai 2021
Journal
Journal of gynecology obstetrics and human reproduction
Auteurs
Membres identifiés du Cancéropôle Est :
Pr VABRES Pierre
,
Dr BONNET Céline
,
Pr GAUCHOTTE Guillaume
Tous les auteurs :
Agopiantz M, Sorlin A, Vabres P, Leheup B, Carmignac V, Malaplate-Armand C, Diligent C, Bonnet C, Gauchotte G
Lien Pubmed
Résumé
The molecular basis of McCune Albright syndrome (MAS) is a recurrent GNAS Postzygotic gain of function sporadic mutation, resulting in a mosaic disease. Most of girls present precocious puberty, caused by the development of recurrent ovarian cysts with autonomous Hyperestrogenic stimulation. After menarche, the majority of patients with ovarian GNAS mutation have menstrual disturbances and infertility.
Mots clés
Anti Mullerian Hormone (AMH), Fertility, In Vitro Fertilization (IVF), McCune Albright Syndrome, Pregnancy
Référence
J Gynecol Obstet Hum Reprod. 2021 May 25;50(9):102171
