Predictors of disease-free survival in colorectal cancer with microsatellite instability: An AGEO multicentre study.

Date publication

mai 2015

Journal

European journal of cancer (Oxford, England : 1990)

Auteurs

Membres identifiés du Cancéropôle Est :
Dr MOUILLET Guillaume , Dr VERNEREY Dewi

Tous les auteurs :
Tougeron D, Sickersen G, Mouillet G, Zaanan A, Trouilloud I, Coriat R, Aparicio T, Des Guetz G, Lecaille C, Artru P, Cauchin E, Sefrioui D, Boussaha T, Ferru A, Matysiak-Budnik T, Silvain C, Karayan-Tapon L, Pagès JC, Vernerey D, Bonnetain F, Michel P, Taïeb J, Lecomte T,

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25864037

Résumé

A microsatellite instability (MSI) phenotype is found in about 12% of colorectal cancers (CRCs) and is associated with a low recurrence rate after curative surgery. Several studies have identified clinical and pathological factors predictive of recurrence in resected CRC, but not in the MSI subgroup.

Mots clés

Aged, Aged, 80 and over, Biomarkers, Tumor, genetics, Chemotherapy, Adjuvant, Colorectal Neoplasms, diagnosis, Colorectal Neoplasms, Hereditary Nonpolyposis, diagnosis, Digestive System Surgical Procedures, Disease-Free Survival, Female, Humans, Male, Microsatellite Instability, Middle Aged, Prognosis, Retrospective Studies

Référence

Eur. J. Cancer. 2015 May;51(8):925-34