TCR Clonality and Genomic Instability Signatures as Prognostic Biomarkers in High Grade Serous Ovarian Cancer.

Fiche publication

Date publication

août 2021

Journal

Cancers

Auteurs

Membres identifiés du Cancéropôle Est :
Dr ARNOULD Laurent , Dr BOIDOT Romain , Pr GHIRINGHELLI François , Mme TRUNTZER Caroline , Dr DERANGERE Valentin , Dr FUMET Jean-David , Dr ALBUISSON Juliette , Dr GOUSSOT Vincent

Tous les auteurs :
Lecuelle J, Boidot R, Mananet H, Derangère V, Albuisson J, Goussot V, Arnould L, Tharin Z, Ray Coquard I, Ghiringhelli F, Truntzer C, Fumet JD

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/34503204

Résumé

Immune infiltration is a prognostic factor in high-grade serous ovarian carcinoma (HGSC) but immunotherapy efficacy is disappointing. Genomic instability is now used to guide the therapeutic value of PARP inhibitors. We aimed to investigate exome-derived parameters to assess the tumor microenvironment according to genomic instability profile.