Integrative genomics analysis of nasal intestinal-type adenocarcinomas demonstrates the major role of CACNA1C and paves the way for a simple diagnostic tool in male woodworkers.

Fiche publication

Date publication

septembre 2021

Journal

Clinical epigenetics

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis , Dr HOULGATTE Rémy , Pr JANKOWSKI Roger , Pr GAUCHOTTE Guillaume , Dr OUSSALAH Abderrahim , Pr GALLET Patrice

Tous les auteurs :
Gallet P, Oussalah A, Pouget C, Dittmar G, Chery C, Gauchotte G, Jankowski R, Gueant JL, Houlgatte R

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/34563241

Résumé

Nasal intestinal-type adenocarcinomas (ITAC) are strongly related to chronic wood dust exposure: The intestinal phenotype relies on CDX2 overexpression but underlying molecular mechanisms remain unknown. Our objectives were to investigate transcriptomic and methylation differences between healthy non-exposed and tumor olfactory cleft mucosae and to compare transcriptomic profiles between non-exposed, wood dust-exposed and ITAC mucosa cells.