Brain adiponectin signaling controls peripheral insulin response in Drosophila.

Date publication

septembre 2021

Journal

Nature communications

Auteurs

Membres identifiés du Cancéropôle Est :
Mr HAMMANN Philippe

Tous les auteurs :
Arquier N, Bjordal M, Hammann P, Kuhn L, Léopold P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/34561451

Résumé

The brain plays a key role in energy homeostasis, detecting nutrients, metabolites and circulating hormones from peripheral organs and integrating this information to control food intake and energy expenditure. Here, we show that a group of neurons in the Drosophila larval brain expresses the adiponectin receptor (AdipoR) and controls systemic growth and metabolism through insulin signaling. We identify glucose-regulated protein 78 (Grp78) as a circulating antagonist of AdipoR function produced by fat cells in response to dietary sugar. We further show that central AdipoR signaling inhibits peripheral Juvenile Hormone (JH) response, promoting insulin signaling. In conclusion, we identify a neuroendocrine axis whereby AdipoR-positive neurons control systemic insulin response.

Référence

Nat Commun. 2021 Sep 24;12(1):5633