Neutrophil-to-lymphocyte ratio is correlated to driver gene mutations in surgically-resected non-small cell lung cancer and its post-operative evolution impacts outcomes.

Fiche publication

Date publication

août 2021

Journal

Clinical lung cancer

Auteurs

Membres identifiés du Cancéropôle Est :
Pr FALCOZ Pierre-Emmanuel , Pr GAUCHOTTE Guillaume , Dr STREIT Arthur

Tous les auteurs :
Seitlinger J, Prieto M, Guerrera F, Streit A, Gauchotte G, Siat J, Falcoz PE, Massard G, Ferri L, Spicer J, Renaud S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/34583910

Résumé

We sought to evaluate prognostic value of neutrophil-to-lymphocyte ratio (NLR) in surgically resected non-small cell lung cancer (NSCLC) and its correlation to oncogenic drivers. We retrospectively reviewed data of patients who underwent anatomic lung resection for NSCLC and whose mutational status was known, from 4 department of thoracic surgery, over the period 2008 to 2019. Primary endpoints were overall survival (OS) and time to recurrence (TTR). Clinical and molecular factors were investigated in the univariate and multivariate analysis for their association with the primary endpoints.