Fiche publication
Date publication
janvier 2021
Journal
Molecular & cellular oncology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DAVIDSON Irwin
Tous les auteurs :
Coassolo S, Davidson I
Lien Pubmed
Résumé
Conversion of peptidyl-arginine to peptidyl citrulline, known as citrullination, is a post-translational protein modification catalyzed by the PADI (Protein Arginine Deiminase) family of enzymes. PADI1 and PADI3 catalyze citrullination of arginine 106 in the glycolytic enzyme pyruvate kinase M2 modulating its allosteric regulation, glycolysis and cancer cell proliferation.
Mots clés
NuRD complex, allosteric regulation, chromatin, melanoma, protein arginine deiminase
Référence
Mol Cell Oncol. 2021 ;8(4):1927446
