Next-Generation Sequencing and Genotype Association Studies Reveal the Association of HLA-DRB3*02:02 With Delayed Hypersensitivity to Penicillins.

Date publication

octobre 2021

Journal

Allergy

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis , Dr OUSSALAH Abderrahim

Tous les auteurs :
Romano A, Oussalah A, Chery C, Guéant-Rodriguez RM, Gaeta F, Cornejo-Garcia JA, Rouyer P, Josse T, Mayorga C, Torres MJ, Guéant JL

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/34687232

Résumé

Nonimmediate (delayed) allergic reactions to penicillins are common and some of them can be life-threatening. The genetic factors influencing these reactions are unknown/poorly known/poorly understood. We assessed the genetic predictors of a delayed penicillin allergy that cover the HLA loci.

Mots clés

Amoxicillin, Beta-lactams, Drug allergy, Genome-wide association, HLA-DRB3, Nonimmediate reactions, Penicillins

Référence

Allergy. 2021 Oct 23;: