Joint modelling with competing risks of dropout for longitudinal analysis of health-related quality of life in cancer clinical trials.

Date publication

novembre 2021

Journal

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CONROY Thierry

Tous les auteurs :
Cuer B, Conroy T, Juzyna B, Gourgou S, Mollevi C, Touraine C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/34817733

Résumé

Health-related quality of life (HRQoL) is an important endpoint in cancer clinical trials. Analysis of HRQoL longitudinal data is plagued by missing data, notably due to dropout. Joint models are increasingly receiving attention for modelling longitudinal outcomes and the time-to-dropout. However, dropout can be informative or non-informative depending on the cause.

Mots clés

Clinical trials, Competing risks, Health-related quality of life, Joint modelling, Missing data, Oncology

Référence

Qual Life Res. 2021 Nov 24;: