Fiche publication
Date publication
décembre 2021
Journal
Clinical epigenetics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BEZDETNAYA-BOLOTINE Lina
,
Pr GUEANT Jean-Louis
,
Dr OUSSALAH Abderrahim
Tous les auteurs :
Siblini Y, Chéry C, Rouyer P, Raso J, Julien A, Hergalant S, François A, Bezdetnaya L, Vogin G, Guéant JL, Oussalah A
Lien Pubmed
Résumé
Although radiation therapy represents a core cancer treatment modality, its efficacy is hampered by radioresistance. The effect of ionizing radiations (IRs) is well known regarding their ability to induce genetic alterations; however, their impact on the epigenome landscape in cancer, notably at the CpG dinucleotide resolution, remains to be further deciphered. In addition, no evidence is available regarding the effect of IRs on the DNA methylome profile according to the methionine dependency phenotype, which represents a hallmark of metabolic adaptation in cancer.
Mots clés
Aberrant methylation, Epigenome alterations, Epigenome-wide association study, Glioblastoma, Hepatocellular carcinoma, Ionizing radiation, Melanoma, Metabolic adaptation in cancer, Methionine dependency, Radiation therapy, Radioresistance
Référence
Clin Epigenetics. 2021 Dec 1;13(1):212
