Fiche publication
Date publication
décembre 2013
Auteurs
Membres identifiés du Cancéropôle Est :
Pr VABRES Pierre
Tous les auteurs :
Passeron T, Maza A, Fontas E, Toubel G, Vabres P, Livideanu C, Mazer JM, Rossi B, Boukari F, Harmelin Y, Dreyfus I, Mazereeuw-Hautier J, Lacour JP
Lien Pubmed
Résumé
BACKGROUND: Neoangiogenesis occurs within the following days after laser treatment of port wine stains (PWS), and plays a central role in treatment failures. Topical use of timolol can significantly reduce the production of vascular endothelial growth factor in vitro, and in animal model. OBJECTIVES: The aim of this study was to assess the efficacy of topical timolol in combination with pulsed dye laser (PDL) treatment, as compared to PDL alone, for treating PWS. METHODS: Prospective multicenter controlled trial performed in children with PWS of the face who had not previously received laser treatment. After randomization, one group was treated with PDL alone, and the other with PDL followed by twice daily applications of timolol gel. Three laser sessions were performed at one month intervals with fixed parameters. The evaluation was performed on standardized pictures by two independent physicians blinded to the treatment received. The primary endpoint was marked or complete improvement of the PWS (Investigator Global Assessment (IGA) 3 or 4) one month after the third session. RESULTS: Twenty-two children were included. Two patients were lost to follow-up. There was no difference in the success rate between the two groups (IGA 3 or 4 observed in 1 patient /10 and 2 patients /12, for PDL alone, and for PDL associated with topical timolol, respectively (p=1.0)). No side effect related to the application of topical timolol was observed. CONCLUSIONS: The adjunction of timolol gel for preventing neoangiogenesis failed to significantly improve the efficacy of PDL treatment of PWS. This article is protected by copyright. All rights reserved.
Référence
Br J Dermatol. 2013 Dec 6
