Characterization of novel interactions with membrane NEU1 highlights new regulatory functions for the Elastin Receptor Complex in monocyte interaction with endothelial cells.

Date publication

décembre 2021

Journal

Cell & bioscience

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BLAISE Sébastien , Dr DUCA Laurent , Pr MARTINY Laurent , Dr TERRYN Christine , Dr BENNASROUNE Amar

Tous les auteurs :
Bocquet O, Tembely D, Rioult D, Terryn C, Romier B, Bennasroune A, Blaise S, Sartelet H, Martiny L, Duca L, Maurice P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/34903296

Résumé

Vascular aging is associated with remodeling of elastin, one of the main extracellular matrix component of the arterial wall, and production of elastin-derived peptides (EDP). These extracellular matrix degradation products have been shown to trigger biological activities through the elastin receptor complex (ERC) and data from the last decade have brought significant insights on the critical role played by its NEU1 subunit in the biological effects mediated by EDP and the ERC in vascular and metabolic diseases.

Mots clés

Desialylation, Elastin peptides, Elastin receptor complex, Elastin remodeling, Endothelial cells, Membrane glycoproteins, Monocytes, NEU1

Référence

Cell Biosci. 2021 Dec 13;11(1):206