Digestive n-6 Lipid Oxidation, a Key Trigger of Vascular Dysfunction and Atherosclerosis in the Western Diet: Protective Effects of Apple Polyphenols.

Fiche publication

Date publication

mars 2021

Journal

Molecular nutrition & food research

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GENY Bernard

Tous les auteurs :
Bolea G, Philouze C, Dubois M, Risdon S, Humberclaude A, Ginies C, Charles AL, Geny B, Reboul C, Arnaud C, Dufour C, Meyer G

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/33450108

Résumé

A main risk factor of atherosclerosis is a Western diet (WD) rich in n-6 polyunsaturated fatty acids (PUFAs) sensitive to oxidation. Their oxidation can be initiated by heme iron of red meat leading to the formation of 4-hydroxy-2-nonenal (4-HNE), a cytotoxic aldehyde. An increased 4-HNE production is implicated in endothelial dysfunction and atherosclerosis. By contrast, a diet rich in proanthocyanidins reduces oxidative stress and arterial diseases. This study evaluates the effects of a WD on vascular integrity in ApolipoproteinE (ApoE ) mice and the protective capacity of apple extract and puree rich in antioxidant proanthocyanidins.