Critical Limb Ischaemia Exacerbates Mitochondrial Dysfunction in ApoE-/- Mice Compared with ApoE+/+ Mice, but N-acetyl Cysteine still Confers Protection.

Fiche publication

Date publication

octobre 2019

Journal

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GENY Bernard

Tous les auteurs :
Lejay A, Charles AL, Georg I, Goupilleau F, Delay C, Talha S, Thaveau F, Chakfé N, Geny B

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31422047

Résumé

The current study was performed in order to determine the influence of hypercholesterolaemia on critical limb ischaemia (CLI) and whether targeting oxidative stress by antioxidant therapies such as N-acetyl cysteine (NAC), considered to be a direct scavenger of reactive oxygen species, could confer muscle protection.