Fiche publication
Date publication
août 2019
Journal
Antioxidants & redox signaling
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GENY Bernard
Tous les auteurs :
Marchandot B, Kibler M, Charles AL, Trinh A, Petit Eisenmann H, Zeyons F, Von Hunolstein JJ, Reydel A, Matsushita K, Kindo M, Hoang Minh T, Leddet P, De Poli F, Messas N, Jesel L, Ohlmann P, Geny B, Morel O
Lien Pubmed
Résumé
Reactive oxygen species (ROS) are central bioenergetic markers linked to aortic stenosis (AS) development and severity. We sought to evaluate the time course and impact of ROS assessed by plasmatic superoxide anion (SA) among patients undergoing transcatheter aortic valve replacement (TAVR). Among 106 patients, SA significantly decreased after TAVR. Dropped values were measured 10 min after TAVR (0.590 ± 0.181 0.648 ± 0.193; < 0.001) and persistent at 3 days (0.611 ± 0.0.228 0.646 ± 0.199; = 0.033) and 30 days follow-up (0.572 ± 0.207 0.639 ± 0.199; = 0.005). Increased baseline SA (>75 percentile) was continuously associated with higher postprocedural SA values 10 min after valve expansion ( < 0.001), at 3 days ( < 0.001) and 30 days ( < 0.001). Higher baseline SA was linked to higher inflammatory response assessed by higher C-reactive protein values at day 1 and day 3. The composite endpoint of all-cause mortality and/or stroke and/or pacemaker implantation and/or significant paravalvular aortic regurgitation ≥mild at 30 days did not differ significantly according to SA baseline values ( = 0.055). This is the first report identifying a decrease in oxidative stress level after TAVR. Our observation leads to the hypothesis that oxidative stress biomarkers may survive the journey from bench to bedside in AS and TAVR and become new biomarkers with both diagnostic and prognostic values. 31, 420-426.
Mots clés
aortic stenosis, oxidative stress, superoxide anion, transcatheter aortic valve replacement
Référence
Antioxid Redox Signal. 2019 08 10;31(5):420-426
