Fiche publication
Date publication
janvier 2016
Journal
Antioxidants & redox signaling
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GENY Bernard
,
Dr ZOLL Joffrey
Tous les auteurs :
Bouitbir J, Singh F, Charles AL, Schlagowski AI, Bonifacio A, Echaniz-Laguna A, Geny B, Krähenbühl S, Zoll J
Lien Pubmed
Résumé
Although statins are the most widely used cholesterol-lowering agents, they are associated with a variety of muscle complaints. The goal of this study was to characterize the effects of statins on the mitochondrial apoptosis pathway induced by mitochondrial oxidative stress in skeletal muscle using human muscle biopsies as well as in vivo and in vitro models.
Mots clés
Animals, Apoptosis, drug effects, Deltoid Muscle, cytology, Glycolysis, drug effects, Hydrogen Peroxide, metabolism, Hydroxymethylglutaryl-CoA Reductase Inhibitors, adverse effects, Male, Mitochondria, drug effects, Muscle, Skeletal, cytology, Muscular Diseases, chemically induced, Oxidative Stress, drug effects, Rats, Rats, Wistar, Reactive Oxygen Species, metabolism, Signal Transduction, drug effects
Référence
Antioxid Redox Signal. 2016 Jan 10;24(2):84-98
