Fiche publication
Date publication
janvier 2016
Journal
Hypoxia (Auckland, N.Z.)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FAVRET Fabrice
Tous les auteurs :
Pichon A, Jeton F, El Hasnaoui-Saadani R, Hagström L, Launay T, Beaudry M, Marchant D, Quidu P, Macarlupu JL, Favret F, Richalet JP, Voituron N
Lien Pubmed
Résumé
Despite its well-known role in red blood cell production, it is now accepted that erythropoietin (Epo) has other physiological functions. Epo and its receptors are expressed in many tissues, such as the brain and heart. The presence of Epo/Epo receptors in these organs suggests other roles than those usually assigned to this protein. Thus, the aim of this review is to describe the effects of Epo deficiency on adaptation to normoxic and hypoxic environments and to suggest a key role of Epo on main physiological adaptive functions. Our original model of Epo-deficient (Epo-TAg) mice allowed us to improve our knowledge of the possible role of Epo in O homeostasis. The use of anemic transgenic mice revealed Epo as a crucial component of adaptation to hypoxia. Epo-TAg mice survive well in hypoxic conditions despite low hematocrit. Furthermore, Epo plays a key role in neural control of ventilatory acclimatization and response to hypoxia, in deformability of red blood cells, in cerebral and cardiac angiogenesis, and in neuro- and cardioprotection.
Mots clés
Epo-TAgh mice, hypoxia, mouse model, physiological functions
Référence
Hypoxia (Auckl). 2016 ;4:29-39
