Left Ventricular Transmural Gradient in Mitochondrial Respiration Is Associated with Increased Sub-Endocardium Nitric Oxide and Reactive Oxygen Species Productions.

Fiche publication

Date publication

janvier 2016

Journal

Frontiers in physiology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GENY Bernard

Tous les auteurs :
Kindo M, Gerelli S, Bouitbir J, Hoang Minh T, Charles AL, Mazzucotelli JP, Zoll J, Piquard F, Geny B

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/27582709

Résumé

Left ventricle (LV) transmural gradient in mitochondrial respiration has been recently reported. However, to date, the physiological mechanisms involved in the lower endocardium mitochondrial respiration chain capacity still remain to be determined. Since, nitric oxide (NO) synthase expression in the heart has spatial heterogeneity and might impair mitochondrial function, we investigated a potential association between LV transmural NO and mitochondrial function gradient.