Temporal trends in initiation of mineralocorticoid receptor antagonists and risk of subsequent withdrawal in patients with heart failure: A nationwide study in Denmark from 2003-2017.

Fiche publication

Date publication

décembre 2021

Journal

European journal of heart failure

Auteurs

Membres identifiés du Cancéropôle Est :
Pr ROSSIGNOL Patrick

Tous les auteurs :
Zahir D, Bonde A, Madelaire C, Malmborg M, Butt JH, Fosbol E, Gislason G, Torp-Pedersen C, Andersson C, Rossignol P, McMurray JJV, Kober L, Schou M

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/34969178

Résumé

Despite landmark heart failure (HF) with reduced ejection fraction (HFrEF) trials showing effect of Mineralocorticoid Receptor Antagonists (MRA) on the risk of death and HF hospitalization, it has been suggested that MRAs are underutilized or frequently withdrawn. This study sought to identify temporal trends in the initiation of MRAs and the subsequent risk of withdrawal and adherence of MRAs in HF patients treated with a renin-angiotensin system inhibitor and a beta-blocker in Denmark from 2003-2017.