Adverse Mechanical Ventilation and Pneumococcal Pneumonia Induce Immune and Mitochondrial Dysfunctions Mitigated by Mesenchymal Stem Cells in Rabbits.

Date publication

décembre 2021

Journal

Anesthesiology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BENSOUSSAN Danièle , Mme BATAILLE Amandine , Dr REPPEL Loïc

Tous les auteurs :
Blot M, Jacquier M, Pauchard LA, Rebaud C, Marlin C, Hamelle C, Bataille A, Croisier D, Thomas C, Jalil A, Mirfendereski H, Piroth L, Chavanet P, Bensoussan D, Laroye C, Reppel L, Charles PE

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/34965287

Résumé

Mechanical ventilation for pneumonia may contribute to lung injury due to factors that include mitochondrial dysfunction, and mesenchymal stem cells may attenuate injury. This study hypothesized that mechanical ventilation induces immune and mitochondrial dysfunction, with or without pneumococcal pneumonia, that could be mitigated by mesenchymal stem cells alone or combined with antibiotics.

Référence

Anesthesiology. 2021 Dec 29;: