Fiche publication
Date publication
novembre 2021
Journal
Nanomaterials (Basel, Switzerland)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BEZDETNAYA-BOLOTINE Lina
Tous les auteurs :
Farrakhova D, Romanishkin I, Maklygina Y, Bezdetnaya L, Loschenov V
Lien Pubmed
Résumé
Spectroscopic approach with fluorescence time resolution allows one to determine the state of a brain tumor and its microenvironment via changes in the fluorescent dye's fluorescence lifetime. Indocyanine green (ICG) is an acknowledged infra-red fluorescent dye that self-assembles into stable aggregate forms (ICG NPs). ICG NPs aggregates have a tendency to accumulate in the tumor with a maximum accumulation at 24 h after systemic administration, enabling extended intraoperative diagnostic. Fluorescence lifetime analysis of ICG and ICG NPs demonstrates different values for ICG monomers and H-aggregates, indicating promising suitability for fluorescent diagnostics of brain tumors due to their affinity to tumor cells and stability in biological tissue.
Mots clés
H-aggregates, brain cancer, fluorescent diagnosis, fluorescent dyes, fluorescent lifetime, glioma C6, indocyanine green, near-infrared range
Référence
Nanomaterials (Basel). 2021 Nov 24;11(12):
