Fiche publication
Date publication
janvier 2021
Journal
Frontiers in endocrinology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PLATEROTI Michelina
Tous les auteurs :
Sirakov M, Claret L, Plateroti M
Lien Pubmed
Résumé
A pivotal role of thyroid hormones and their nuclear receptors in intestinal development and homeostasis have been described, whereas their involvement in intestinal carcinogenesis is still controversial. In this perspective article we briefly summarize the recent advances in this field and present new data regarding their functional interaction with one of the most important signaling pathway, such as WNT, regulating intestinal development and carcinogenesis. These complex interactions unveil new concepts and will surely be of importance for translational research.
Mots clés
canonical WNT pathway, intestinal carcinogenesis, intestinal epithelium, thyroid hormone receptors, thyroid hormones
Référence
Front Endocrinol (Lausanne). 2021 ;12:725708
