Fiche publication
Date publication
mai 2012
Journal
NeuroImage
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HEITZ Fabrice
,
Pr DE SEZE Jérôme
,
Dr NOBLET Vincent
Tous les auteurs :
Grigis A, Noblet V, Heitz F, Blanc F, de Sèze J, Kremer S, Rumbach L, Armspach JP
Lien Pubmed
Résumé
This paper presents a longitudinal change detection framework for detecting relevant modifications in diffusion MRI, with application to neuromyelitis optica (NMO) and multiple sclerosis (MS). The core problem is to identify image regions that are significantly different between two scans. The proposed method is based on multivariate statistical testing which was initially introduced for tensor population comparison. We use this method in the context of longitudinal change detection by considering several strategies to build sets of tensors characterizing the variability of each voxel. These strategies make use of the variability existing in the diffusion weighted images (thanks to a bootstrap procedure), or in the spatial neighborhood of the considered voxel, or a combination of both. Results on synthetic evolutions and on real data are presented. Interestingly, experiments on NMO patients highlight the ability of the proposed approach to detect changes in the normal-appearing white matter (according to conventional MRI) that are related with physical status outcome. Experiments on MS patients highlight the ability of the proposed approach to detect changes in evolving and non-evolving lesions (according to conventional MRI). These findings might open promising prospects for the follow-up of NMO and MS pathologies.
Mots clés
Algorithms, Brain Mapping, methods, Diffusion Magnetic Resonance Imaging, methods, Humans, Image Interpretation, Computer-Assisted, methods, Multiple Sclerosis, pathology, Neuromyelitis Optica, pathology, ROC Curve
Référence
Neuroimage. 2012 May 1;60(4):2206-21
