Brain-derived Neurotrophic Factor Pathway after Downhill and Uphill Training in Rats.

Date publication

janvier 2019

Journal

Medicine and science in sports and exercise

Auteurs

Membres identifiés du Cancéropôle Est :
Mr PERNET Nicolas

Tous les auteurs :
Pedard M, Cefis M, Ennequin G, Quirié A, Garnier P, Prigent-Tessier A, Pernet N, Marie C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30157106

Résumé

The elevation of brain-derived neurotrophic factor (BDNF) levels in the brain and the subsequent phosphorylation of its cognate tropomyosin-related kinase B (TrkB) receptors at tyrosine 816 (pTrkB) are largely involved in the positive effect of aerobic exercise on brain functioning. Although BDNF levels were reported to increase in proportion with exercise intensity, the effect of the type of contraction is unknown. Therefore, the cerebral BDNF/TrkB pathway was investigated after uphill and downhill treadmill activities at equivalent intensity to preferentially induce eccentric and concentric contractions, respectively.

Mots clés

Animals, Brain, metabolism, Brain-Derived Neurotrophic Factor, metabolism, Muscle Contraction, physiology, Nitric Oxide Synthase Type III, metabolism, Phosphorylation, Physical Conditioning, Animal, methods, Proto-Oncogene Proteins c-fos, metabolism, Rats, Wistar, Receptor, trkB, metabolism, Synaptophysin, metabolism

Référence

Med Sci Sports Exerc. 2019 01;51(1):27-34