Fiche publication
Date publication
février 2013
Journal
Biomolecular concepts
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DAUCHEZ Manuel
,
Pr DEBELLE Laurent
,
Dr DUCA Laurent
,
Pr MARTINY Laurent
,
Dr BRASSART Bertrand
,
Pr BAUD Stéphanie
Tous les auteurs :
Baud S, Duca L, Bochicchio B, Brassart B, Belloy N, Pepe A, Dauchez M, Martiny L, Debelle L
Lien Pubmed
Résumé
Elastin is the protein responsible for the resilience of vertebrate tissue. It is an extremely stable protein deposited during the early stages of life and experiencing almost no renewal. As a consequence, it can be considered that each individual has an elastin capital for life. Despite its extreme stability, elastin can be degraded by several enzymes termed elastases. Elastases are among the most aggressive proteases, and their presence is increased with age. As a consequence, elastin fragmentation resulting in the generation of elastin peptides is one of the hallmarks of aging. This review will examine their nature and further expose our current understanding of the role played by these peptides in aging and their contribution to tissue homeostasis and several pathologies.
Mots clés
Aging, metabolism, Animals, Disease, Elastin, metabolism, Homeostasis, Humans, Peptides, metabolism, Proteolysis
Référence
Biomol Concepts. 2013 Feb;4(1):65-76
