Fiche publication
Date publication
février 2022
Journal
Communications biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr SUMARA Izabela
,
Dr PANGOU Evanthia
Tous les auteurs :
Liao Y, Sumara I, Pangou E
Lien Pubmed
Résumé
Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins that frequently targets substrates for proteasomal degradation. However it can also result in non-proteolytic events which play important functions in cellular processes such as intracellular signaling, membrane trafficking, DNA repair and cell cycle. Emerging evidence demonstrates that dysfunction of non-proteolytic ubiquitylation is associated with the development of multiple human diseases. In this review, we summarize the current knowledge and the latest concepts on how non-proteolytic ubiquitylation pathways are involved in cellular signaling and in disease-mediating processes. Our review, may advance our understanding of the non-degradative ubiquitylation process.
Référence
Commun Biol. 2022 Feb 8;5(1):114
